Agmatine as a tissue protective compound, and a painkiller

Albert Kossel, Nobel laureate discovered agmatine in 1910

Albert Kossel, Nobel laureate discovered agmatine in 1910

Agmatine [(NH2(CH2)4NH2C(NH=)NH], is a metabolite of the amino acid arginine, was discovered by Nobel laureate Albrecht Kossel (16 September 1853 – 5 July 1927) in 1910. It is a naturally occurring molecule ubiquitously found in nature, which is biosynthesized by decarboxylation of the amino acid arginine (itself a dietaryingredient), thus known as decarboxylated arginine.

Agmatine is found in abundance in foodstuff derived from plants, fish, with levels as-high-as 200 to 650 mg/kg found in certain fish, and animal products. Importantly, normal agmatine fecal concentrations are the highest among amines, at 14.42 μmol/g dry weight.

Microbial production ofagmatine, therefore, is considered important source for absorption of agmatine into the body by the mucosal lining of the large intestine.

Agmatine Effects on our organs

There is quite some evidence from laboratory animal studies indicates that treatment with agmatine has beneficial health promoting effects on various organs, tissues and bodily functions: agmatine has a number of biological effects, it is:

  1. mild antihypertensive,
  2. cardioprotective,
  3. neuroprotective, and
  4. nephroprotective.

Of specific interest, is the substantial body of evidence demonstrating the beneficial effects of agmatine on the nervous system. These include neuroprotection, anticonvulsive effects, and anti-anxiety and anti-depressive effects.

In this section you find more on this remarkable tissue protective natural compound.

Here the first description by prof. Kossel of agmatine, from his paper published in 1910, and the relation to the amino acid arginine he already detected:

Agmatine and arginine by Kossel in 1910

Agmatine and arginine

Agmatine and arginine


Kossel, Albrecht 1910. Über das AgmatinZeitschrift für Physiologische Chemie 66: 257-261


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